{"id":3619,"date":"2023-05-15T19:19:16","date_gmt":"2023-05-16T01:19:16","guid":{"rendered":"https:\/\/sites.library.ualberta.ca\/ior-2020\/?page_id=3619"},"modified":"2023-05-17T13:23:43","modified_gmt":"2023-05-17T19:23:43","slug":"engineering-in-nanospace","status":"publish","type":"page","link":"https:\/\/sites.library.ualberta.ca\/ior-2020\/semifinalists-2023\/engineering-in-nanospace","title":{"rendered":"Engineering in Nanospace"},"content":{"rendered":"\n

Semi-finalist 2023<\/h4>\n\n\n\n
\n
\n
\"\"<\/a><\/figure>\n<\/div>\n\n\n\n
\n
Submitted by:<\/td>Jeff Tao<\/td><\/tr>
Department:<\/td>Laboratory Medicine and Pathology<\/td><\/tr>
Faculty:<\/td>Medicine & Dentistry<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n

Here, I\u2019ve illustrated myself constructing a nanodevice called a \u201cDNAzyme Walker\u201d on the surface of a gold nanoparticle. The astronaut suit represents how, like astronauts who journey to outer space thousands of kilometers away in rockets, we navigate within nanospace, which is millions of times smaller than a centimeter, through chemistry and microscopy. Although the DNAzyme is synthesized with the biological material DNA, I\u2019ve drawn the DNAzyme to be more machine-like to depict its mechanical function of cleaving nearby DNA. The strand the DNAzyme is cleaving is a string of DNA that tethers fluorophores to the surface of gold nanoparticles (which are redder when nanometers in size). Gold nanoparticles uniquely quench green fluorescence near its surface, which is why the tethered fluorophores are shaded grey in the illustration. After cleavage, the fluorophore is distanced from the nanoparticle and evokes a recordable fluorescence, represented by the green orbs in the background of the image. We designed this contraption to respond to cancer markers to release fluorophores or chemotherapies to both detect and destroy cancer cells.<\/p>\n\n\n\n

<\/p>\n\n\n\n

<\/p>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

Semi-finalist 2023 Submitted by: Jeff Tao Department: Laboratory Medicine and Pathology Faculty: Medicine & Dentistry Here, I\u2019ve illustrated myself constructing a nanodevice called a \u201cDNAzyme Walker\u201d on the surface of a gold nanoparticle. The astronaut suit represents how, like astronauts who journey to outer space thousands of kilometers away in rockets, we navigate within nanospace, […]<\/p>\n","protected":false},"author":3,"featured_media":0,"parent":3690,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"class_list":["post-3619","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/sites.library.ualberta.ca\/ior-2020\/wp-json\/wp\/v2\/pages\/3619","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/sites.library.ualberta.ca\/ior-2020\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/sites.library.ualberta.ca\/ior-2020\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/sites.library.ualberta.ca\/ior-2020\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/sites.library.ualberta.ca\/ior-2020\/wp-json\/wp\/v2\/comments?post=3619"}],"version-history":[{"count":3,"href":"https:\/\/sites.library.ualberta.ca\/ior-2020\/wp-json\/wp\/v2\/pages\/3619\/revisions"}],"predecessor-version":[{"id":3751,"href":"https:\/\/sites.library.ualberta.ca\/ior-2020\/wp-json\/wp\/v2\/pages\/3619\/revisions\/3751"}],"up":[{"embeddable":true,"href":"https:\/\/sites.library.ualberta.ca\/ior-2020\/wp-json\/wp\/v2\/pages\/3690"}],"wp:attachment":[{"href":"https:\/\/sites.library.ualberta.ca\/ior-2020\/wp-json\/wp\/v2\/media?parent=3619"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}